Ογκο-Υπερθερμία: Ο τέταρτος πυλώνας στην ογκολογία μαζί με την Χημειοθεραπεία – Ακτινοθεραπεία  Χειρουργική

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Hyperthermia and the Therapy of Malignant Tumors

Recent Results in Cancer Research Volume 104, 1987, pp 24-70

The Biological Basis for Tumour Therapy by Hyperthermia and Radiation

C. Streffer, D. van Beuningen

Abstract

The use of hyperthermia in treatment of cancers has a long tradition. One of the oldest medical texts describes the treatment of a breast tumour with hyperthermia.

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Int J Radiat Oncol Biol Phys. 1986 (12): 1661-167 

Original Contdbution 

MICROWAVE HYPERTHERMIA AS AN ADJUNCT TO RADIATION THERAPY: EXPERIENCE OF 256 MULTIFRACTION TREATMENT CASES

H BICHER, R WOLFSTEIN, S. LEWINSKY, ET AL

 SUMMARY

Results in 256 cases of malignant disease treated by multifraction combination hyperthermia-radiation therapy under the supervision of one physician are presented.

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Int J Radiat Oncol Biol Phys. 1992;22(5):989-98.

Relationships among tumor temperature, treatment time, and histopathological outcome using preoperative hyperthermia with radiation in soft tissue sarcomas.

Leopold KA, Dewhirst M, Samulski T, Harrelson J, Tucker JA, George SL, Dodge RK, Grant W, Clegg S, Prosnitz LR, et al.

Source

Department of Radiation Oncology, Duke University Medical Center, Durham, NC 27710.

Abstract

The lack of an unambiguous thermal dosimetry continues to impede progress in clinical hyperthermia. In an attempt to define better this dosimetry, a model based on the cumulative minutes

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J Cancer Res Clin Oncol. 1980;98(1):15-29.

Circulatory and metabolic responses of malignant tumors during localized hyperthermia.

Vaupel P, Ostheimer K, Müller-Klieser W.

Abstract

The effect of localized hyperthermia on the circulatory responses and on the oxygen and glucose supply has been evaluated in tissue-isolated rat tumors utilizing an in situ perfusion system.

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Natl Cancer Inst Monogr. 1982 Jun;61:19-26.

Effect of microenvironmental factors on the response of cells to single and fractionated heat treatments.

Gerweck LE.

Abstract

The thermal sensitivity of cells is substantially influenced by variations in the concentration of hydrogen ions, glucose, and oxygen under certain conditions.

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Radiat Res. 2001 Apr;155(4):515-28.

Improvement of tumor oxygenation by mild hyperthermia.

Song CW, Park H, Griffin RJ.

Source

Department of Therapeutic Radiology-Radiation Oncology, University of Minnesota Medical School, 420 Delaware Street SE, MMC 494, Minneapolis, MN 55455, USA.

Abstract

There is now abundant evidence that oxygenation in rodent, canine and human tumors is improved during and for up to 1-2 days after heating at mild temperatures.

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Radiology. 1977 May;123(2):463-74.

Cellular responses to combinations of hyperthermia and radiation.

Dewey WC, Hopwood LE, Sapareto SA, Gerweck LE.

Abstract

The two principal rationales for applying hyperthermia in cancer therapy are that: (a) the S phase, which is relatively radioresistant, is the most sensitive phase to

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Radiology. 1980 Nov;137(2):523-30.

Effects of hyperthermia on normal and tumor microenvironment.

Bicher HI, Hetzel FW, Sandhu TS, Frinak S, Vaupel P, O'Hara MD, O'Brien T.

Abstract

The effects of hyperthermia on pH, local blood flow (LBF) and tissue oxygen tension (TpO2) in several normal and tumor tissues were studied.

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Ann Oncol. 2002 Aug;13(8):1173-84.

Heating the patient: a promising approach?

van der Zee J.

Source

Erasmus Medical Center-Daniel den Hoed Cancer Center, Department of Radiation Oncology, Hyperthermia Unit, Rotterdam, The Netherlands. This email address is being protected from spambots. You need JavaScript enabled to view it.

Abstract

There is a clear rationale for using hyperthermia in cancer treatment. Treatment at temperatures between 40 and 44 degrees C is cytotoxic for cells in an environment with a low pO(2) and low pH, conditions that are found specifically within tumour tissue, due to insufficient blood perfusion. Under such conditions radiotherapy is less effective, and

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Future Oncol. 2012 Aug;8(8):1041-9. doi: 10.2217/fon.12.90.

10-year single-center experience of combined intravesical chemohyperthermia for nonmuscle invasive bladder cancer.

Moskovitz B, Halachmi S, Moskovitz M, Nativ O, Nativ O.

Source

The Department of Urology, Bnai Zion Medical Center, Haifa 31048, Israel.

Abstract

AIM:

Owing to the limited efficacy and significant toxicity of most topical intravesical agents for the management of nonmuscle invasive bladder cancer (NMIBC), a search for new

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Int J Hyperthermia. 2009 Dec;25(8):610-6. doi: 10.3109/02656730903315831.

Heat shock proteins and immunity: application of hyperthermia for immunomodulation.

Torigoe T, Tamura Y, Sato N.

Source

Department of Pathology, Sapporo Medical University School of Medicine, Sapporo, Japan. This email address is being protected from spambots. You need JavaScript enabled to view it.

Abstract

Heat shock proteins (HSPs) play an important role as 'endogenous danger signals' in the immune surveillance system. Extracellular HSPs released from damaged cells can stimulate professional antigen-presenting cells, followed by cytokine release and expression of cell surface molecules. In addition to such activity stimulating innate immunity, extracellular

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Int J Hyperthermia. 2001 Jan-Feb;17(1):1-18.

Hyperthermia in oncology.

Falk MH, Issels RD.

Source

Medizinische Klinik III, Klinikum Grosshadern, Munich, Germany.

Abstract

The purpose of this article is to provide an overview on the

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Crit Rev Oncol Hematol. 2002 Jul;43(1):33-56.

The cellular and molecular basis of hyperthermia.

Hildebrandt B, Wust P, Ahlers O, Dieing A, Sreenivasa G, Kerner T, Felix R, Riess H.

Source

Medical Clinic, Department of Hematology and Oncology, Charite Medical School, Humboldt-University, Campus Virchow Clinic, D-13344 Berlin, Germany. This email address is being protected from spambots. You need JavaScript enabled to view it.

Abstract

In oncology, the term 'hyperthermia' refers to the treatment of malignant diseases by administering heat in various ways. Hyperthermia is usually applied as an adjunct to an already established treatment modality (especially radiotherapy and chemotherapy), where tumor temperatures in the range of 40-43 degrees C are aspired. In several clinical

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J Clin Oncol. 2003 Dec 15;21(24):4560-7.
Analysis of factors associated with outcome in patients with malignant peritoneal mesothelioma undergoing surgical debulking and intraperitoneal chemotherapy.
Feldman AL, Libutti SK, Pingpank JF, Bartlett DL, Beresnev TH, Mavroukakis SM, Steinberg SM, Liewehr DJ, Kleiner DE, Alexander HR.
Source
Surgical Metabolism Section, Surgery Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.
Abstract
PURPOSE:
Malignant mesothelioma (MM) arising in the peritoneal cavity is a rare neoplasm characterized by peritoneal progression and for which there are limited therapeutic options. We evaluated the peritoneal progression-free and overall survival (PFS and OS, respectively) for patients with peritoneal MM after surgical resection and regional chemotherapy.

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